内源性奥雷克辛和迪诺芬相关释放对投影定义的腹部体多巴胺神经元产生明显的神经调节效应
Aida Mohammadkhani1, Min Qiao1, Stephanie L Borgland2
1Department of Physiology and Pharmacology, Hotchkiss Brain Institute, The University of Calgary, Calgary, AB T2N 4N1, Canada.
概括
来自横向下丘脑的奥雷克辛和迪诺芬神经分别调节腹膜区域的多巴胺神经元活动,影响寻求奖励的行为.
科学领域:
- 神经科学是一个神经科学.
- 神经生物学 神经生物学 神经生物学
- 行为神经科学 行为神经科学
背景情况:
- 腹部体区域 (VTA) 的多巴胺 (DA) 神经元对于有动机的行为至关重要.
- 侧向体下垂体 (LH) 神经甲氨基酸 (ox) 和氨基酸 (dyn) 联合表达,并投射到静脉动脉.
- 这些对VTA DA神经元通过素1 (Ox1R) 和卡帕阿片类受体 (KOR) 发射具有相反的作用,在它们的净效果中产生模糊性.
研究的目的:
- 为了研究如何光学刺激LH牛/神经元调节VTA DA神经元活动.
- 根据VTA DA投影目标 (BLA,lAcbSh,mAchSh) 来确定LH氧/释放分离的作用.
主要方法:
- 利用电路跟踪,光遗传学,和补丁电生理学在素-cre小鼠.
- 研究了Ox1R和KOR信号在调解观察到的效应中的作用.
- 研究了LH氧/刺激对向不同大脑区域投射的VTA DA神经元的影响.
主要成果:
- 在VTA DA神经元发射中,LH氧/光学刺激诱导了不同的反应,独立于快速神经递质释放.
- 这些效应被Ox1R和KOR抗剂阻断.
- 刺激抑制了投射BLA的VTA DA神经元,但双向影响了投射lAcbSh和mAchSh的VTA DA神经元.
结论:
- LH氧/合释放酶通过差异调节VTA DA神经元组合,将其投射到不同的目标.
- 这种体系统可以通过平衡不同VTA DA通路中的神经元活动来微调寻求奖励的行为.
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