青少年跨性别医学中的临床药理学
Lauren R Cirrincione1, Kai J Huang2, Gina M Sequeira3,4
1Department of Pharmacy, University of Washington, Seattle, WA, USA.
British journal of clinical pharmacology
|August 26, 2024
概括
对跨性别年轻人性别肯定药物的研究发现,没有研究关于激素释放激素 (GnRH) 激动剂如何影响药物的药理动力学. 需要进一步的研究,以了解这些影响在青少年.
科学领域:
- 药理学 药理学是指药理学的学科.
- 内分泌学 在内分泌学.
- 青少年医学 青少年医学
背景情况:
- 青少年跨性别医学是一个不断扩大的领域.
- 性别确认药物,包括GnRH激动剂和激素,用于跨性别青年.
- GnRH激动剂用于抑制青春期.
研究的目的:
- 评估GnRH激动剂对跨性别年轻人药理学过程的潜在影响.
- 确定现有的研究对GnRH激动剂对跨性别青少年药物吸收,分发,新陈代谢或分泌的影响.
- 检查GnRH激动剂对影响青春期药物代谢的激素的影响.
主要方法:
- 从PubMed的开始到2024年5月,进行了系统的文献搜索.
- 搜索了关于GnRH激动剂对跨性别青少年药理动学的影响的出版物.
- 包括对影响一般青少年人口药物代谢的荷尔蒙变化的研究.
主要成果:
- 没有出版物直接讨论了GnRH激动剂对跨性别青少年药理学过程的影响.
- 十六篇出版物显示,跨性别男性和女性的性腺激素和性类固醇显著下降.
- 观察到对上腺激素的轻微影响,与 cisgender 年轻人相比,跨性别年轻人的身体组成变化更大.
结论:
- 在跨性别青少年中缺乏研究GnRH激动剂的药理动力学效应.
- GnRH激素治疗显著影响跨性别年轻人的激素水平和身体组成.
- 进一步的研究是必不可少的,以了解药物代谢和GnRH激动剂在这个人群中的药理学影响.
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