一次剂量鼻内活减弱码子去优化疫苗提供了针对SARS-CoV-2及其变种的广泛保护
Xiang Liu1,2,3, Wern Hann Ng1,2,3, Eva Zusinaite4
1Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia.
Nature communications
|August 26, 2024
概括
一种新的鼻入疫苗CDO-7N-1提供了针对SARS-CoV-2变种的广泛保护. 这种活体减弱疫苗诱导强烈的免疫反应,并在单剂量后在多种动物模型中预防感染.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 给全球健康和经济带来了持续的挑战.
- 目前的尖蛋白疫苗在提供对新兴变种的长期保护和防止传播方面存在局限性.
研究的目的:
- 开发和评估一种新的鼻内活减弱SARS-CoV-2疫苗 (CDO-7N-1),以提供广泛的保护.
- 在临床前模型中评估CDO-7N-1的免疫性和疗效.
主要方法:
- 使用SARS-CoV-2的代码子去优化生成了CDO-7N-1.
- 疫苗的有效性和免疫性在小鼠,仓鼠和身上进行了评估.
- 动物受到野生型SARS-CoV-2和令人担忧的变种的挑战.
主要成果:
- 在体内,CDO-7N-1表现出高度减弱的复制和最小的肺病理.
- 一次免疫接种诱导了强大的粘膜和全身中和抗体和T细胞反应.
- 接种疫苗的动物被保护免受SARS-CoV-2和变种的挑战,并与SARS-CoV-1进行交叉中和.
结论:
- 鼻内注射的CDO-7N-1是一种有前途的疫苗候选人,可诱导对SARS-CoV-2及其变种的广泛免疫力.
- 对所有SARS-CoV-2蛋白质的免疫力可能会增强对未来变种的疗效.
- 进一步开发可以解决当前疫苗的局限性,并改善流行病控制.
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