维生素D水平作为2型糖尿病运动障碍综合征的预测指标
Yongfang Ma1, Bowei Liu2, Fuzai Yin1
1The First Hospital of Qinhuangdao, No.258 Wenhua Road, Qinhuangdao, 066000, Hebei Province, People's Republic of China.
Scientific reports
|August 26, 2024
概括
低维生素D水平预测2型糖尿病患者的运动不良综合征 (DMS). 这种以移动性问题为特征的疾病,在维生素D缺乏和糖尿病控制不良的情况下更为普遍.
科学领域:
- 老年学和内分泌学.
- 代谢和肌肉骨健康
背景情况:
- 失能综合征 (DMS) 是一种类似于代谢综合征的复杂疾病,影响了运动能力.
- 2型糖尿病 (T2DM) 患者经常经历影响身体功能的并发症.
- 在T2DM中,25-基维生素D [25-(OH) 维生素D]和DMS之间的关系需要进一步调查.
研究的目的:
- 探索25-OH) 维生素D水平与T2DM患者的DMS患病率之间的关联.
- 为了确定该人群中DMS的风险因素,包括维生素D状态.
主要方法:
- 一项涉及330名T2DM患者 (平均年龄67.0±8.8岁) 的横截面研究.
- 收集的数据包括握力,步行速度,25-(OH) 维生素D水平和骨矿物质密度 (DXA).
- 如果患者有六种情况中的三种或更多:骨质疏松症,肌肉质量/力量低,步行速度慢,跌倒或肥胖,则诊断出DMS.
主要成果:
- DMS的患病率为25.5%,其中67.9%的T2DM患者表现出维生素D缺乏 (<36.2nmol/L).
- 与没有DMS的患者相比,患有DMS的患者的维生素D水平显著降低25-(OH) (41.74 ± 14.60与47.19 ± 13.01,P <0.05).
- DMS风险的独立预测因素包括年龄较大 (OR=1.160),HbA1c较高 (OR=1.262),以及维生素D缺乏 (OR=2.990).
结论:
- 较低的25-OH) 维生素D水平是T2DM患者运动不便综合征的重要预测因素.
- 维生素D缺乏,晚年和血糖控制不良 (高HbA1c) 与增加DMS风险有关.
- 这些发现强调了评估和管理T2DM患者的维生素D状况的重要性,以减轻移动性问题.
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