在微生理系统中规范设计和新出现的定量特征
Dennis M Nahon1, Renée Moerkens2, Hande Aydogmus3
1Leiden University Medical Center, Leiden, the Netherlands.
Nature biomedical engineering
|August 26, 2024
概括
为微生理系统 (MPS) 或芯片器官制定标准对于比较它们对人类的相关性至关重要. 这确保了准确的药物毒性评估和疾病建模.
科学领域:
- 生物医学工程 生物医学工程
- 在体外建模模型.
- 生理系统生理系统.
背景情况:
- 微生理系统 (MPS) 是先进的体外细胞模型,模仿器官功能.
- 与传统的细胞培养不同,MPS结合了机械刺激和流体流动等生理线索.
- 这些系统通常被称为"芯片上的器官",具有更大的生理相关性.
研究的目的:
- 倡导在MPS中开发标准化的定量生理特征.
- 确保MPS在特定应用中的体内相关性和预测能力.
- 促进MPS技术的更广泛的最终用户采用和监管接受.
主要方法:
- 使用来自血管,肠道,大脑和心脏MPS的例子.
- 区分设计特征 (可通过MPS设计控制) 和新兴特征 (细胞功能).
- 建议使用读数和传感器加强MPS监控的方法.
主要成果:
- 强调需要标准化的定量生理特征来进行MPS之间的比较.
- 展示MPS设计参数与观察到的细胞功能之间的区别.
- 确定在MPSs中对复杂生理学的定量监测策略.
结论:
- 标准化对于验证MPS在药物开发和疾病研究中的预测能力至关重要.
- 对生理特征的定量监测是提高MPS准确性和可靠性的关键.
- 标准化的MPS将加速其融入监管流程和科学发现.
相关概念视频
Units and Standards of Measurement
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A standard set of units has been defined to...
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A physical quantity is defined either by specifying its measurement method or by stating how it is calculated from other measurements. For example, consider a metallic cube. We might define its mass and dimensions by specifying methods for measuring them, such as using a weighing machine and a meter scale. Then, we could define the volume by stating that it is the cube of its side, and we could calculate the density as the mass divided by the volume.
Measurements of physical quantities are...
Measurements of physical quantities are...
Mechanical Systems
Mechanical systems are analogous to to electrical networks where springs and masses play similar roles to inductors and capacitors, respectively. A viscous damper in mechanical systems functions similarly to a resistor in electrical networks, dissipating energy. The forces acting on a mass in such systems include an applied force in the direction of motion, counteracted by forces from the spring, a viscous damper, and the mass's acceleration. This interplay of forces is mathematically described...
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