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在叶中桃体子区域的异常功能连接与ictal恐慌的

Xiao Zhang¹, Xuemei Chen¹, Chuanyong Qu¹

¹Department of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People's Republic of China.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

|August 26, 2024

概括

经历了ictal恐慌的叶患者表现出杏仁体子区域的功能连接性改变,特别是底侧杏仁体和中枢杏仁体. 大脑网络中的这些变化为恐惧神经电路提供了洞察力.

科学领域:

神经科学是一个神经科学.
的研究研究.
功能神经成像功能神经成像

背景情况:

杏仁体在处理恐惧和恐慌方面发挥着至关重要的作用.
叶 (TLE) 可能涉及复杂的神经现象,包括眼膜恐慌 (IP).
了解TLE中IP的神经机制对于有针对性的治疗至关重要.

研究的目的:

研究具有IP的TLE患者中杏仁体亚区域的功能连接性 (FC) 改变.
探索叶症中ictal恐慌背后的神经机制.

主要方法:

休息状态功能性磁共振成像 (rs-fMRI) 在18名具有IP的TLE患者 (TLE-IP),23名没有IP的TLE患者 (TLE-无IP) 和22名健康对照 (HC) 上进行.
分析了底侧 (BLA),中枢 (CMA) 和表面 (SFA) 杏仁体子区域的功能连接性.
基于杏仁体亚区域的FC在三组中进行了比较.

主要成果:

与TLE-none-IP和HC组相比,TLE-IP组在左下侧杏仁体 (BLA) 和右中额头 (MFG) 之间的FC增加.
在TLE-IP组中,在右侧BLA和右侧后中心之间观察到增强的FC.
在TLE-IP组的左中枢桃体 (CMA) 和子之间发现了降低的FC,并进一步改变了与丘脑和前骨的连接.

结论:

杏仁体子区域内的异常功能连接在TLE患者中显而易见.
这些发现有助于理解TLE中的恐惧神经电路,并可能为未来的治疗策略提供信息.

关键词:

阿米格达拉的一个桃体.恐慌的恐慌是一种恐慌.休息状态的功能连接.时间叶发作时间叶.

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