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基于PSMA Aptamer的双功能PET和光探头的临床前评估

Sudong Kong^1,2,3, Ying Peng², Qingzhu Liu²

¹School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China.

Bioconjugate chemistry

|August 26, 2024

概括

一个新的双模式成像探测器[Ga]Ga-NOTA-PSMA-Cy5,显示了早期前列腺癌检测的希望. 这种探针专门针对前列腺特异性膜抗原 (PSMA),有助于准确的诊断和手术指导.

科学领域:

在瘤学瘤学.
医疗成像医学成像
生物技术是生物技术.

背景情况:

前列腺癌是全球男性的主要恶性瘤.
早期和准确的检测对于防止过度治疗至关重要.
前列腺特异性膜抗原 (PSMA) 是一个关键的诊断生物标志物.

研究的目的:

开发一种双模式成像探针,用于增强前列腺癌诊断.
在体外和体内评估探针对PSMA的特异性和敏感性.
评估其用于光导向手术的潜力.

主要方法:

通过自动化固相寡核酸合成合成NOTA-PSMA-Cy5前体.
准备双模式探头[Ga]Ga-NOTA-PSMA-Cy5.5 的情况
在实验室中使用流细胞计,光成像和PSMA表达细胞中的细胞吸收试验进行评估.
在体内评估使用正子发射断层扫描/近红外光 (PET/NIRF) 成像.

主要成果:

[Ga]Ga-NOTA-PSMA-Cy5探头在体外显示出有利的光特性和稳定性.
在LNCaP和PC-3细胞中证实了探针与PSMA的特定结合.
在体内PET/NIRF成像证实了敏感和特定的PSMA向.
探测器成功地可视化了PSMA阳性癌症病变.

结论:

开发的PET/NIRF双模式探头 ([Ga]Ga-NOTA-PSMA-Cy5) 是前列腺癌诊断的一个有前途的工具.
它准PSMA的能力有助于精确检测和定位癌症.
该探针有可能通过识别PSMA阳性病变来指导外科干预.

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