导电性水凝@碳纤维电极作为一种新型的内神经接口的表征
Alice Giannotti1,2, Ranieri Santanché3, Ciro Zinno1,2
1The Biorobotic Institute, Scuola Superiore Sant'Anna, Piazza Martiri Della Libertà 33, 56127, Pisa, Italy.
Bioelectronic medicine
|August 26, 2024
概括
这项研究为生物电子医学引入了一种新的碳纤维内核接口. 该设备增强神经信号检测和生物相容性,以改善假肢控制和治疗.
科学领域:
- 生物电子医学 生物电子医学
- 神经工程 神经工程是神经工程.
- 生物材料科学 生物材料科学
背景情况:
- 外围神经接口对生物电子医学至关重要,可控制假肢和治疗干预.
- 内神经接口提供高选择性,但在生物相容性和长期信号稳定性方面面临挑战.
- 目前的局限性包括慢性免疫反应和信号降解,阻碍临床转化.
研究的目的:
- 开发和描述使用碳纤维捆绑的新型内神经接口.
- 为了增强外围神经应用的生物相容性和信号传导.
- 解决神经接口中传统金属电极的局限性.
主要方法:
- 使用碳纤维捆绑制造一个神经内接口.
- 整合了由PEDOT:PSS水凝制成的3D稳定结构,以提高生物相容性.
- 用弹性材料涂覆碳纤维捆绑,用于电气绝缘.
- 结构性,电化学性和生物相容性属性的基板表征.
主要成果:
- 碳纤维捆绑显示低阻抗,改善信号检测和刺激效率.
- PEDOT:PSS 水凝结构增强了接口与神经组织的生物相容性.
- 弹性体涂层提供了有效的电绝缘.
- 开发的电极显示出适用于外围神经刺激和记录的适当特性.
结论:
- 新型的碳纤维内核接口提供了有前途的结构和电化学性能.
- 该设计解决了长期神经接口的关键生物相容性挑战.
- 这一进步有可能改善生物电子医学应用,包括假肢和神经治疗.
相关概念视频
Facilitated Transport
14.6K
The chemical and physical properties of plasma membranes cause them to be selectively permeable. Since plasma membranes have both hydrophobic and hydrophilic regions, substances need to be able to transverse both regions. The hydrophobic area of membranes repels substances such as charged ions. Therefore, such substances need special membrane proteins to cross a membrane successfully. In facilitated transport, also known as facilitated diffusion, molecules and ions travel across a...
14.6K
Electrical Synapses
10.1K
Electrical synapses found in all nervous systems play important and unique roles. In these synapses, the presynaptic and postsynaptic membranes are very close together (3.5 nm) and are actually physically connected by channel proteins forming gap junctions.
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
10.1K
Ligand-gated Ion Channels
11.4K
Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
11.4K
Electrochemical Gradient and Channel Proteins: An Overview
4.9K
An electrochemical gradient is a fundamental concept in biology and chemistry. It regulates the movement of ions across cell membranes. This movement is influenced by two factors:
The electrical gradient: The electrical gradient across cell membranes refers to the difference in electric charge between the inside and outside of a cell. This difference drives the movement of ions towards or away from the cells. For instance, if the inside of the cell is more negatively charged relative to...
The electrical gradient: The electrical gradient across cell membranes refers to the difference in electric charge between the inside and outside of a cell. This difference drives the movement of ions towards or away from the cells. For instance, if the inside of the cell is more negatively charged relative to...
4.9K
The Electrical Double Layer
241
In the region where two bulk phases meet, an intricate electric charge distribution arises due to charge transfer, ion adsorption, molecular orientation, and charge distortion. This complex distribution is commonly referred to as the electrical double layer.When a solid electrode interfaces with ions in an electrolyte solution, the speed of electron transfer dictates the rates of oxidation and reduction. The electrode acquires a charge through the escape of atoms into the solution as cations or...
241
Neuronal Communication
5.5K
Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...
5.5K


