在患有酒精使用障碍的患者中,对急性压力产生改变的生理,情感和功能连接反应
Yana Schwarze1,2, Johanna Voges3, Alexander Schröder1,2
1Social Neuroscience Lab, Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany.
Biological psychiatry global open science
|August 27, 2024
概括
患有酒精使用障碍 (AUD) 的个体表现出形的生理应激反应,但增加了情感痛苦. 神经成像揭示了AUD中功能连接的改变,影响了压力调节,并提供了治疗见解.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 成研究 研究成研究
背景情况:
- 酒精使用障碍 (AUD) 与急性压力处理的改变有关.
- 对于AUD的同时应激参数反应和神经机制的理解有限.
研究的目的:
- 研究AUD患者的生理和情感应激反应.
- 在AUD中检查与压力相关的功能性大脑连接性改变.
主要方法:
- 在压力和控制条件下收集了34名AUD参与者和34名对照者的唾液皮质醇,脉率和影响评分.
- 利用功能磁共振成像 (fMRI) 来评估功能连接,专注于AUD和与压力相关的大脑区域.
主要成果:
- AUD参与者表现出心率减弱和皮质醇对压力的反应,但情感反应更强烈.
- fMRI揭示了功能连接中与压力相关的显著差异,特别是涉及条形和后置默认模式网络种子.
结论:
- 研究结果表明,在AUD中,主观痛苦和生理应激反应之间存在分离.
- 确定了与压力相关的功能连接性改变,突出了酒精使用和压力调节之间的复杂相互作用,为潜在的治疗策略提供了信息.
更多相关视频
相关概念视频
Stress and Mental Health
89
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
89
Psychological Responses to Stress
49
Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
49
Introduction to Stress and Lifestyle
91
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
91
CNS Depressants: Alcohol and Nicotine
183
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
183
Substance Use Disorders Affecting Sleep
163
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
163
Altered States of Awareness
164
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
164


