系统炎症反应指数与冠心病之间的关系:一个横截面研究 (NHANES 2007-2016)
Tian Yang Zhang1, Hai Long Chen1, Yanyu Shi1
1College of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
系统炎症反应指数 (SIRI) 与冠心病 (CHD) 的更高风险有关. 这种关联在女性中尤为明显,这表明SIRI是潜在的心脏病风险生物标志物.
科学领域:
- 心血管研究研究心血管研究
- 炎症生物标志物 炎症生物标志物
- 公共卫生 公共卫生
背景情况:
- 冠心病 (CHD) 是一种普遍的慢性疾病,通常与炎症过程有关.
- 系统炎症反应指数 (SIRI) 已成为全身炎症的新生物标志物.
研究的目的:
- 调查SIRI与患心脏病的风险之间的关联.
- 通过使用国家健康和营养检查调查 (NHANES) 的数据来探索这种关系.
主要方法:
- 一项横截面研究分析了2007-2016年NHANES数据,针对40岁及以上的参与者.
- 用物流回归和限制立方线 (RCS) 分析来评估SIRI-CHD关系.
- 进行了分层子组分析,以检查各种人口和临床因素之间的相互作用.
主要成果:
- 较高的SIRI水平与心脏病风险增加显著相关 (OR1.12,95% CI:1.03-1.22).
- 在女性中观察到SIRI和CHD风险之间的显著相互作用,但在其他子组中没有.
- 证实了SIRI和CHD风险之间的线性关系,没有证据表明非线性.
结论:
- 升高的SIRI是增加心脏病风险的重要指标.
- SIRI和CHD之间的关联在女性中尤为明显.
- SIRI可以作为一个有价值的炎症生物标志物来评估心脏病风险分层.
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