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Updated: Jun 15, 2025

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
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Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Published on: October 4, 2019

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利用多omics数据推断mRNA 3'终端处理在质母细胞瘤中的调节者

Aleksei Mironov1, Lorenzo Franchitti2, Shreemoyee Ghosh1

  • 1Biozentrum, University of Basel, Basel, Switzerland.

Frontiers in molecular biosciences
|August 27, 2024
PubMed
概括

这项研究确定了RNA结合蛋白 (RBP) 与质母细胞瘤 (GBM) 瘤中的替代多基化 (APA) 的关联. 它揭示了新的RBP-APA链接,提供了对癌症生物学和潜在治疗点的见解.

关键词:
编码编码 编码编码在RBP中使用RBP.在TCGA中,TCGA就是TCGA.替代性的多基化.质母细胞瘤是什么

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Regulated mRNA Transport

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mRNA Stability and Gene Expression

The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
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Pre-mRNA Processing: Modification of pre-mRNA Ends

In eukaryotic cells, transcripts made by RNA polymerase are modified and processed before exiting the nucleus. Unprocessed RNA is called precursor mRNA or pre-mRNA to distinguish it from mature mRNA.
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