在50岁以下的一级亲属中,发展为1型糖尿病的风险较大
Ines Urrutia1,2, Rosa Martinez1,2, Begona Calvo1,3
1Biobizkaia Health Research Institute, Barakaldo, Spain.
Frontiers in endocrinology
|August 27, 2024
概括
具有多个胰腺自身抗体的第一级亲属,特别是儿童和青少年,更快地发展为1型糖尿病 (T1D). 早期检测和年轻亲属的风险因素评估对于T1D预防策略至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 遗传学 遗传学 是一个
背景情况:
- 在1型糖尿病 (T1D) 患者的一级亲属中检测胰腺自身抗体表明疾病风险.
- 新兴的免疫疗法需要识别有风险的个体,以便及时进行干预.
- 了解自身免疫性进展是主动T1D管理的关键.
研究的目的:
- 评估T1D患者的一级亲属的自身免疫力.
- 估计自免疫检测到临床T1D发病的时间.
- 确定与加速T1D进展相关的风险因素.
主要方法:
- 对3,015名一级亲属 (1992-2018) 的回顾性多中心研究.
- 胰腺自身抗体 (IAA,GADA,IA2A,ZnT8A) 的放射性免疫测试的确定.
- 亲属具有积极的自身免疫和正常葡萄糖水平的随访;使用考克斯模型和卡普兰-梅尔图表进行统计分析.
主要成果:
- 在21个祖先和27个兄弟姐妹中检测到阳性自身抗体.
- 54.2%的自身免疫的亲属在5年的中位数内发展出T1D.
- 较快的T1D进展与多个自身抗体和20岁之前的检测有关.
结论:
- 患有多个自身抗体的儿童和青少年更快地发展为T1D.
- 患有自身免疫的年轻人也处于风险之中,因此有必要将其纳入查.
- 基于年龄和自身抗体配置的风险分层可以指导T1D预防工作.
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