心脏再同步治疗急性心力衰竭和左捆支部阻塞在现实生活中的注册表中
Oriol Aguiló1,2, Joan Carles Trullàs2,3, Begoña Espinosa4,5,6
1Hospital d'Olot i Comarcal de la Garrotxa, Emergency Department, Girona, Catalonia, Spain.
Colombia medica (Cali, Colombia)
|August 27, 2024
概括
心脏再同步疗法 (CRT) 在急性心力衰竭 (AHF) 和左捆支部阻塞 (LBBB) 的患者中未得到充分使用和延迟. 这种使用不足意味着CRT不会改善这些患者的长期存活率.
科学领域:
- 心脏病学 心脏病学
- 心脏衰竭管理的管理
- 医疗器械 医疗器械
背景情况:
- 左捆支部阻塞 (LBBB) 是急性心力衰竭 (AHF) 患者的常见发现.
- 心脏再同步疗法 (CRT) 是心力衰竭和LBBB的选定患者的治疗选择.
- 在LBBB的AHF患者中,关于CRT使用和结果的现实数据有限.
研究的目的:
- 评估LBBB的AHF患者中CRT实施的患病率,特征和时间.
- 评估CRT对该患者群体的长期全因死亡率的影响.
- 在现实环境中识别CRT使用障碍.
主要方法:
- 对EAHFE (流行病学急性心力衰竭紧急情况) 队列的分析.
- 包括患有AHF和LBBB的患者.
- 评估CRT的指示,时间和10年所有原因的死亡率.
- 符合CRT标准的CRT治疗和未治疗患者之间的结局的比较.
主要成果:
- 只有6%的LBBB的AHF患者接受了CRT,平均延迟960天.
- 接受CRT的患者年轻,有不同的并发症,以及左下心室喷射率 (LVEF).
- 与未接受CRT治疗的患者相比,CRT与10年全因死亡率显著降低无关.
结论:
- 在现实实践中,在LBBB的AHF患者中,CRT显著延迟并未充分利用.
- 目前在这个人群中使用CRT的模式似乎没有改善长期全因死亡率.
- 需要制定战略来改善及时和适当的CRT实施.
相关概念视频
Heart Failure Drugs: β-Blockers
324
β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
324
Heart Failure Drugs: Inotropic Agents
545
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
545
Pulse rhythm
775
Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
775
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
405
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
405


