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Updated: Jun 15, 2025

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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Published on: January 22, 2019

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对针对Janus kinase 3 (JAK3) 的pyrazolopyrimidine衍生物的合理设计和虚拟选的计算洞察力

Abdelmoujoud Faris1, Ivana Cacciatore2, Radwan Alnajjar3

  • 1LIMAS, Department of Chemical Sciences, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, Fez, Morocco.

Frontiers in chemistry
|August 27, 2024
PubMed
概括

新型皮拉佐洛皮里米丁化合物显示出 Janus 激酶3 (JAK3) 抑制剂的潜力,用于治疗类风湿性关节炎. 计算方法确定了具有良好的安全概况的强效衍生品,与现有药物相比.

关键词:
这就是JAK3的意义.自身免疫性疾病 自身免疫性疾病癌症 癌症 癌症 癌症 癌症类风湿性关节炎 类风湿性关节炎铁氨酸激酶酶的使用方法

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