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妇女生物流体中非必不可少的微量元素与euploid单胚胎移植周期中的试管婴儿结果之间的关联

Roberto Gonzalez-Martin¹, Andrea Palomar¹, Silvia Perez-Deben¹

¹IVI-RMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), 46026 Valencia, Spain.

Journal of xenobiotics

|August 27, 2024

概括

这项研究发现,某些非必需元素如,和会对体外受精 (IVF) 的结果产生负面影响,包括植入和活产率. 然而,尿路中的鲁比与受精和胚胎细胞发育有积极的关联.

科学领域:

生殖毒理学生殖毒理学
环境健康环境健康
在体外受精过程中受精.

背景情况:

重金属/金属化物与生殖结果之间存在不一致的关联.
非必要的微量元素可能会影响人类的生育能力和试管婴儿的成功.

研究的目的:

评估10种非必不可少的微量元素的生物流体度与西班牙妇女体外受精结果之间的关联.
确定可能对生育治疗产生负面或积极影响的特定因素.

主要方法:

分析了51名接受试管婴儿 (ICSI,PGT-A,SET/FET) 的女性的卵泡液,全血和尿液.
使用ICP-MS和Tricell DMA-80测量了Hg,Pb,As,Ba,Sr,Rb,Cs,Sn,Ni和Co的度.
与卵巢反应,受精,胚胎细胞发育,植入,怀孕和活产率相关的元素度.

主要成果:

卵泡液中和的升高与卵巢反应不佳和植入前结果有关.
在VOR日的高全血/和尿///锡与更糟糕的植入前结果相关.
在VOR日的高尿路红与增强的受精和胚胎细胞发育有关.
过度的全血和尿 (在胚胎移植日) 与植入,怀孕和活产的几率较低有关.

结论:

一些非必不可少的元素 (如,,,,) 似乎对人类IVF结果产生不利影响.
尿路红可能对试管婴儿的特定阶段产生有益影响.
需要对更大的种群进行进一步的研究,并对元素形式的差异化进行进一步的研究,以证实这些初步发现.

关键词:

在ICP-MS中,使用的是ICP-MS.试管婴儿的结果三元 DMA 80 的三元 DMA 80 的三元.生物流体是一种生物流体.非基本的微量元素.卵巢反应的反应

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