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探索由蛋白质分解诱导的内在无序蛋白质的降解 是-关联蛋白质 准金马

Chen Zhou1, Chunbao Sun2, Miao Huang3,4

  • 1Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.

Journal of medicinal chemistry
|August 27, 2024
PubMed
概括

科学家们开发了针对YAP的新型降解剂,使用向蛋白质溶解的嵌合体技术. 这些降解剂有效地降低了YAP的致癌活性,显示了治疗YAP驱动癌症的前景.

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