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肝细胞癌患者免疫疗法对身体组成的预后影响

Lilong Zhang^1,2,3, Xinyi Li^1,2,3, Kunpeng Wang^1,2,3

¹Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, China.

Annals of medicine

|August 27, 2024

概括

在接受免疫检查点抑制剂 (ICI) 的肝细胞癌 (HCC) 患者中,肉类和低骨肌肉指数 (SMI) 与较差的结果有关. 保持足够的肌肉质量和脂肪可以提高治疗的有效性.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
身体组成分析身体成分分析

背景情况:

肝细胞癌 (HCC) 是一个重要的全球健康问题.
免疫检查点抑制剂 (ICI) 已成为HCC的有希望的治疗方法.
身体成分对HCCICI治疗结果的影响尚未完全理解.

研究的目的:

调查用ICI治疗的HCC患者的身体组成参数,肉类和临床结果之间的关系.
在这个患者队列中,评估骨肌肉指数 (SMI) 和皮下脂肪指数 (SAI) 的预后值.

主要方法:

在Embase,PubMed和Cochrane图书馆数据库中进行了系统的文献审查.
包括到2024年1月21日发表的研究,重点是身体组成,肉症和HCC的ICI治疗.
纽卡斯尔-太华尺度评估了研究质量;对于整体存活率 (OS),无进展存活率 (PFS),客观反应率 (ORR) 和疾病控制率 (DCR) 提取了危险比率 (HR) 和几率比率 (OR).

主要成果:

对15篇文章 (1543名患者) 的分析显示,低SMI与明显较低的OS,PFS,ORR和DCR有关.
与缺乏相比,萨科佩尼亚与较差的OS,PFS,ORR和DCR有显著的联系.
更高的SAI水平与更好的OS和PFS相关.

结论:

麻症和低SMI与接受ICI的HCC患者的治疗反应较差和长期存活率降低有关.
身体组成参数,特别是肌肉质量和脂肪组织,是ICI治疗HCC的重要预后因素.
对营养干预和身体组成优化的进一步研究可能会改善接受免疫治疗的HCC患者的结果.

关键词:

身体组成身体组成肝细胞癌是肝细胞癌.免疫检查点抑制剂免疫检查点抑制剂这种类型的麻症是sarcopenia.骨架肌肉指数是指的皮下脂肪指数是指皮下脂肪指数.

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