喷泉循环患者预测的峰值氧气消耗的百分比:快速系统范围审查和验证研究
Curtis A Wadey1, Owen W Tomlinson1,2, Alan R Barker1
1Department of Public Health and Sport Science, Children's Health & Exercise Research Centre (CHERC), Faculty of Health and Life Sciences University of Exeter United Kingdom.
Journal of the American Heart Association
|August 27, 2024
概括
这项研究发现,在评估先天性心脏病患者的峰值氧气消耗时,各种规范性参考值 (NRV) 被不一致地使用,并且经常被报告得很差. 瓦塞尔曼NRV虽然很常见,但在Fontan循环队列中显示出很差的有效性.
科学领域:
- 心脏病学 心脏病学
- 运动生理学 运动生理学
- 遗传性心脏病研究 遗传性心脏病研究
背景情况:
- 峰值氧气消耗 (峰值VO2) 是患有先天性心脏病 (CHD) 的个体的一个关键指标.
- 它通常以年龄和性别匹配的规范基准值 (NRV) 来得出的预测值的百分比来报告.
- 在CHD人群中NRV的适当性和有效性需要进行批判性评估.
研究的目的:
- 确定在涉及心脏病中VO2峰值的研究中使用的特定NRV.
- 在这个人群中评估NRV应用的准确性和适当性.
- 评估常见推的NRV的有效性,当用于患有心脏病的人.
主要方法:
- 一个系统的范围审查确定了相关的研究报告高峰VO2百分比的预测值在CHD.
- 修改过的偏差风险工具被用于评估包含的研究的质量.
- 美国心脏协会推的NRV的有效性使用Fontan循环队列进行了检查.
主要成果:
- 45项研究报告了峰值VO2百分比,但只有47%详细说明了计算方法.
- 瓦瑟曼 (n=12) 和库珀和韦勒-拉维尔 (n=7) 是最常被引用的NRV.
- 瓦塞尔曼NRV的有效性较差,在Fontan队列中没有与测量的峰值VO2显著相关 (男性:R2≤0.01;女性:R2=0.02).
结论:
- 广泛的NRV应用于心脏病患者,通常报告不足和应用不匹配.
- 经常引用的瓦塞尔曼NRV在适用于Fontan循环的个体时缺乏有效性.
- 对于在心血管疾病中进行峰值VO2评估,有必要对经过验证并一致应用的NRV产生关键需求.
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