炎症,免疫血栓和自身免疫反循环可能导致长期COVID中持续的中性粒细胞自我刺激
Alain R Thierry1,2, Dominique Salmon3
1IRCM, Institute of Research on Cancerology of Montpellier, INSERM U1194, University of Montpellier, Montpellier, France.
Journal of medical virology
|August 27, 2024
概括
中性粒细胞和中性粒细胞外细胞陷 (NETs) 可能通过在SARS-CoV-2感染后创建自我维持的炎症,免疫血栓和自身免疫循环来驱动长期的COVID.
科学领域:
- 免疫学 免疫学 免疫学
- 病理生理学 病理生理学
- 病毒学 病毒学
背景情况:
- 长期COVID病理生理学仍然是当代医学的一个重大挑战.
- 在SARS-CoV-2感染和后急性后果之间的直接联系尚未完全理解.
- 中性粒细胞和中性粒细胞外细胞陷 (NETs) 涉及各种炎症状况.
研究的目的:
- 调查中性粒细胞和NETs在长期COVID病理生理学的作用.
- 假设一种机制,涉及由SARS-CoV-2感染引发的积极反循环.
- 探索长期COVID中炎症,免疫血栓和自身免疫的相互联系.
主要方法:
- 该研究提出了一个基于当前分子,细胞和生理观察的假设模型.
- 它考虑了SARS-CoV-2和中性粒细胞之间的直接相互作用.
- 它研究了经过急性感染阶段持续生产NET的潜力.
主要成果:
- 假设SARS-CoV-2感染触发了涉及中性粒细胞和NETs的积极反循环.
- 表明直接与中性粒细胞结合的SARS-CoV-2会导致过度和长时间的NETs产生.
- 提出这种持续的NETs释放驱动系统性炎症,免疫血栓形成和自身免疫.
结论:
- 中性粒细胞和NETs失调被假设为长期COVID的中心机制.
- 这种机制涉及相互连接的炎症,免疫血栓和自身免疫循环.
- 持续的NETs产生可能是长期COVID中观察到的持续器官损伤和血管并发症的基础.
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