马拉塞西亚通过保护的Rim/Pal通道响应环境pH信号
Kaila M Pianalto1,2, Calla L Telzrow1,2, Hannah Brown Harding1,2
1Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
里姆/帕尔 (Rim/Pal) 路径有助于像马拉塞西亚 (Malassezia sympodialis) 这样的真菌适应性pH值,这对于人类皮肤的生长至关重要. 这一途径对于菌在诸如亚托皮性皮肤炎等疾病中生存至关重要.
科学领域:
- 微生物学 微生物学
- 菌类学 菌类学是指菌类学.
- 分子生物学分子生物学
背景情况:
- 微生物适应环境pH值的变化,以求生存.
- 特定于真菌的Rim/Pal信号通路调节了适应性pH的情况.
- 这一途径涉及Rim101/PacC转录因子,对于在中性/性条件下生存至关重要.
研究的目的:
- 调查Rim/Pal通道在人类皮肤上殖民的真菌马拉塞西亚sympodialis中的作用.
- 为了确定微生物适应细胞外应激的保存和类特异性特征.
主要方法:
- 鉴定了马拉塞西亚sympodialis中的假定Rim通路蛋白Rim101和Rra1.
- 利用基因删除 (转配和同源重组) 来创建突变菌株.
- 进行了突变型和野生型菌株的比较转录分析.
- 在皮炎的小鼠模型中评估了真菌生长.
主要成果:
- Rim101和Rra1对于M. sympodialis在更高pH值下生长至关重要.
- 对比转录学揭示了真菌适应性条件的机制.
- 在M. sympodialis中,Rim/Pal通路被保存,并促进性pH的增长.
- Ms Rra1 作为细胞表面的pH传感器,这种传感器在基底菌类真菌中保存着.
- 边缘/手掌信号传递对于M. sympodialis在阿托皮性皮肤炎模型中的生长很重要.
结论:
- 马拉塞西亚sympodialis中保留了Rim/Pal通道,使其能够适应性环境.
- 这一途径在真菌的生存和宿主表面的适应中起着重要作用.
- 这些发现突显了pH感应信号蛋白在真菌病原和宿主相互作用中的重要性,特别是在诸如阿托皮性皮肤炎等疾病中.
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