胆道树的经典病变 胆道树的经典病变
John M Cullen1, David Malarkey2, John R Foster3
1North Carolina State University, Raleigh, North Carolina, USA.
Toxicologic pathology
|August 27, 2024
概括
这项研究回顾了动物因化学暴露而导致的常见胆道树病变,重点关注非新发性发现和术语,如状反应. 它澄清了术语,并讨论了胆纤维化中的潜在瘤变化.
科学领域:
- 毒理学病理学 毒理学病理学
- 肝胆道疾病 肝胆道疾病
- 比较病理学比较病理学
背景情况:
- 胆道树的异常是动物模型中急性和慢性化学暴露后的常见发现.
- 现有的文献,包括INHAND和NTP地图,为了解这些病变提供了基础.
- 毒理病理学会2023年年会强调了需要在这个领域进行当前考虑的必要性.
研究的目的:
- 提供动物胆汁树中常见的非新生病变的概述.
- 讨论各种胆道树病变的发病原因.
- 澄清术语和解决争论的分类,如"圆细胞"与"状反应"以及胆管纤维化瘤潜力.
主要方法:
- 审查以前的出版物和地图集 (INHAND,NTP肝脏非瘤损伤地图).
- 非新发性胆道病变的组织学描述.
- 讨论病原遗传机制和当前的考虑.
主要成果:
- 描述了动物胆汁树中常见的非新形成性发现.
- 对各种病变类别的组织学特征和病原遗传讨论.
- 详细讨论了圆细胞和管状反应之间的区别,以及胆管纤维化病的潜在瘤性质.
结论:
- 准确识别和分类胆汁树病变在毒理病理学中至关重要.
- 澄清术语和理解病原体的帮助在损伤评估.
- 需要进一步研究潜在的瘤病变,如胆管纤维化.
更多相关视频
相关概念视频
Chronic Bowel Disorders: Introduction
420
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
420
Diseases of the Liver and Gallbladder
490
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
490
Gallbladder
435
The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion.
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins...
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins...
435
The Bronchial Tree
2.3K
The human bronchi and bronchial tree play a crucial role in the respiratory system, facilitating the exchange of oxygen and carbon dioxide. Let's delve into the intricate structure and functions of these respiratory components.
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
2.3K
Liver Histology
649
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
Hepatocytes perform a variety of essential functions. They secrete...
649
Bile
679
Bile is a crucial bodily fluid, characterized by its yellow-green color and alkaline nature. Produced in the liver, it is transported through the common hepatic duct into either the cystic duct, leading to the gallbladder, or directly into the common bile duct. The flow of bile is regulated by the sphincter of Oddi located at the entrance of the duodenum. When this sphincter is closed, bile is redirected to the gallbladder for storage and concentration.
Bile is released when dietary fats enter...
Bile is released when dietary fats enter...
679


