铁状况与美国成年人胰岛素抵抗有很强的相关性:全国人口研究
Xue Liu1,2, Yuhao Zhang3, Yuwei Chai1,2
1Department of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, 250021, China.
The Journal of clinical endocrinology and metabolism
|August 27, 2024
概括
较高的铁含量与美国成年人患胰岛素抵抗 (IR) 的风险较低有关. 这项研究探讨了铁状况标志物及其与IR的关联,为未来的研究发现了关键关系.
科学领域:
- 代谢健康 代谢健康
- 营养生物化学 营养生物化学
- 公共卫生 公共卫生
背景情况:
- 关于铁状况标志物与胰岛素抵抗 (IR) 之间的关联的证据有限.
- 了解这种关系对于代谢健康研究至关重要.
研究的目的:
- 调查各种铁状况标志物与IR在美国大量成年人群中的关联.
- 探索潜在的剂量反应关系和铁生物标志物对IR的预测值.
主要方法:
- 利用了来自2003-2006年和2017-2020年国家健康和营养检查调查 (NHANES) 2993名参与者的数据.
- 采用加权线性,多变量逻辑回归和限制立方线 (RCS) 来分析铁状况和IR (HOMA-IR ≥2.5).
- 进行了分层分析和接收器运行特征 (ROC) 曲线分析,以评估预测性能.
主要成果:
- 血清铁 (SI) 与HOMA-IR显示出负相关性.
- 铁摄入量和血清转激素受体 (sTfR) 与IR正相关,而SI和转激素和 (TSAT) 与IR负相关.
- RCS分析显示了sTfR和TSAT与IR的非线性剂量反应关系.
- 与其他铁标记物相比,TSAT显示了IR的优异预测价值.
结论:
- 具体生物标志物显示的铁含量增加与患上胰岛素耐药性的风险显著降低有关.
- 这些发现增强了对铁-红外关系的理解,并为进一步的机理学研究提供了基础.
- 铁状况评估可能在预测IR风险方面发挥作用.
相关概念视频
01:22Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
01:15Diabetes: Symptoms, Diagnosis, and Complications
520
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
520
01:16Insulin: Dosing Regimen and Adverse Effects
161
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
161
01:36Carbohydrate Metabolism
10.9K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.9K
01:28Insulin: The Receptor and Signaling Pathways
1.2K
Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
1.2K