实践:开发一个核心成果集,用于临界疾病的身体康复试验
Bronwen A Connolly1,2,3,4, Matthew Barclay2, Chantal Davies5
1Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom.
Annals of the American Thoracic Society
|August 27, 2024
概括
一个新的核心结果集 (COS) 已开发用于重症成人身体康复研究. 这种标准化的方法将改善临床决策和康复干预措施的元分析.
科学领域:
- 关键护理医学 关键护理医学
- 康复科学是康复的科学.
- 临床试验方法论 临床试验方法论
背景情况:
- 对重症成人体力康复试验的结果选择和报告的异质性限制了元分析和临床决策.
- 需要一种标准化的方法来评估整个重症康复连续性的康复干预措施.
研究的目的:
- 建立一个基于共识的核心成果集 (COS),用于重症成人身体康复研究.
- 在未来的临床试验中确保一致的结果测量.
主要方法:
- 一个国际的,两轮的,在线修改的Delphi共识过程,涉及329名参与者.
- 利益相关者包括来自26个国家的研究人员,临床医生和患者/护理人员.
- 结果根据重要性进行了评分,所有团体都认为那些被认为"至关重要"的结果达到了共识.
主要成果:
- 88% (第一轮) 和91% (第二轮) 的高响应率.
- 建立了一个共识生成的COS,包括:身体功能,日常生活活动,生存,与健康有关的生活质量,运动能力,认知功能,情绪/精神健康和脆弱性.
- 从最初的32项清单中确定了8个关键结果.
结论:
- 已经制定了一项以共识为导向的COS,用于重症成年人的身体康复.
- 这种COS将提高未来研究的一致性和可比性.
- 需要进一步工作来确定推的测量工具来实施COS.
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