相关实验视频

Updated: Jun 15, 2025

Primary Cultures of Rat Astrocytes and Microglia and Their Use in the Study of Amyotrophic Lateral Sclerosis

Primary Cultures of Rat Astrocytes and Microglia and Their Use in the Study of Amyotrophic Lateral Sclerosis

Published on: June 23, 2022

星球细胞与神经元之间的相互作用有助于肌缩侧面硬化症的进展

Brigid K Jensen¹

¹Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA. brigid.jensen@jefferson.edu.

Advances in neurobiology

|August 27, 2024

概括

肌缩性侧面硬化症 (ALS) 涉及运动神经元损伤,其中星球细胞起着关键作用. 本综述详细介绍了星球细胞如何通过改变的通信,在遗传性和零星ALS病例中促进神经毒性.

科学领域:

神经科学是一个神经科学.
遗传学是一个遗传学.
细胞生物学细胞生物学

背景情况:

肌缩侧面硬化症 (ALS) 是一种影响运动神经元的神经退行性疾病,其特点是异质病因和高比例的零星病例.
天体细胞,关键的质细胞,越来越多地被认为是ALS病变的重要贡献者,往往会加剧疾病的进展.
许多遗传突变 (例如,SOD1,TDP43,C9orf72) 和患者衍生的零星病例揭示了涉及星球细胞的神经毒性的多种机制.

研究的目的:

检查星球细胞在ALS病变发生过程中的多方面的作用.
阐明各种遗传和零星ALS形式的星细胞-神经元相互作用的共同点和差异.
提供对ALS中星球细胞介导的神经毒性机制的全面概述.

主要方法:

对不同的ALS遗传形式 (SOD1,TDP43,FUS,C9orf72,VCP,TBK1) 的审查.
在零星的ALS病例中分析患者衍生细胞的发现.
关于天体细胞-神经元通信和质细胞介导的毒性研究的综合.

主要成果:

星球细胞在ALS中从支持性转变为神经毒性作用,导致运动神经元死亡.
常见的特征包括改变的天体细胞-神经元通信,兴奋毒性,氧化应激和炎症.
涉及到特定的途径,比如蛋白质消极平衡,代谢失衡和屏障功能障碍.

结论:

改变的天体细胞-神经元通信是ALS的核心主题,无论疾病的起源如何.
了解这些质贡献对于开发有效的ALS疗法至关重要.
本综述综合了星球细胞介导毒性的关键机制,突出了参与疾病进展的途径.

关键词:

肌缩侧面硬化症 (ALS) 是一种疾病.激发性毒性激发性毒性炎症炎症是一种炎症.代谢失衡是一种代谢失衡.热带因素 (Trophic Factors) 是一种热带因素.

更多相关视频

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis

Published on: July 16, 2021

In vitro Modeling for Neurological Diseases using Direct Conversion from Fibroblasts to Neuronal Progenitor Cells and Differentiation into Astrocytes

In vitro Modeling for Neurological Diseases using Direct Conversion from Fibroblasts to Neuronal Progenitor Cells and Differentiation into Astrocytes

Published on: June 10, 2021

相关概念视频

Amyloid Fibrils

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...

Glial Cells

Glial Cells

Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...