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COVID-19增加了血液透析患者的死亡率:探索与炎症和端粒磨损的联系

Tamara Milosevic^1,2, Radomir Naumovic^3,4, Miron Sopic⁵

¹Laboratory Diagnostics Service, Zvezdara Clinical Hospital Center, Dimitrija Tucovica 161, Belgrade, 11120, Serbia. tamaramedbio@gmail.com.

Molecular biology reports

|August 27, 2024

概括

在血液透析 (HD) 患者中,COVID-19显著增加了死亡率. 死亡的关键预测因素包括COVID-19病史,中性粒细胞与淋巴细胞的比率 (NLR),端粒长度 (TL),C反应蛋白 (CRP) 和乳酸脱酶 (LDH).

科学领域:

腎臟病學 (nephrology) 是一種醫學.
传染性疾病传染性疾病
血液学血液学血液学

背景情况:

血液透析 (HD) 患者面临高死亡风险,特别是在感染大流行冠状病毒 (COVID-19) 时.
了解这种脆弱人群的死亡预测因素对于改善患者的治疗结果至关重要.

研究的目的:

为了确定影响COVID-19阳性HD患者死亡率的参数.
分析中性粒细胞与淋巴细胞比率 (NLR),乳酸脱酶 (LDH),C反应蛋白 (CRP),COVID-19状态和端粒长度 (TL) 的预测值.

主要方法:

一组130名慢性HD患者被跟踪了18个月.
根据COVID-19病史和生存状况对患者进行分组.
评估了实验室参数 (NLR,LDH,CRP) 和TL;使用Kaplan-Meier分析分析的生存预测因素.

主要成果:

死亡的患者年龄较大,BMI,NLR,CRP,LDH高,TL和淋巴细胞较低.
确定了重要的死亡预测因素:COVID-19病史,心血管风险评分,NLR,TL,CRP和LDH.
这些参数的综合风险分数最好预测患者的存活率 (p < 0.001).

结论:

霍乱患者的死亡率仍然很高,COVID-19加剧了这种情况.
特定的生物标志物和临床因素显著预测了COVID-19的HD患者的生存率.
需要进一步的研究和有针对性的干预措施来缓解这一群体的死亡率.

关键词:

在 COVID-19 疫情中,血液透析是血液透析的方法之一.炎症炎症是一种炎症.死亡率死亡率死亡率泰洛米尔 (Telomere) 是一种电离体.

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