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相关概念视频

Development of the Heart01:27

Development of the Heart

901
The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
901

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相关实验视频

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Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery
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在左心室辅助器件支持器件期间形成大动脉根.

Chaztyn Pangelina1, Vi Vu, Karen May-Newman

  • 1From the Department of Mechanical Engineering, Bioengineering Program, San Diego State University, San Diego, California.

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|August 27, 2024
PubMed
概括
此摘要是机器生成的。

大动脉鼻旋对于血液流动至关重要,防止凝块形成. 这项研究可视化了这些流在减少的流量,常见的左心室辅助装置 (LVAD) 支持,突出需要间歇性门打开.

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科学领域:

  • 心血管生理学心血管生理学
  • 生物医学工程 生物医学工程
  • 血液动力学 血液动力学

背景情况:

  • 大动脉鼻旋转优化了血液流动,并防止了血栓形成.
  • 大动脉流量减少,通常与左心室辅助器件 (LVAD) 支持,可以破坏这个,导致停滞和血栓形成.
  • 了解动力学对于管理LVAD患者并发症至关重要.

研究的目的:

  • 在逐渐减少的流量条件下,在实验性大动脉根模型中可视化和分析旋形成.
  • 为了研究左心室辅助器件 (LVAD) 支持对大动脉鼻旋动态的影响.
  • 提供关于旋维持最佳血流并防止静止的机制的见解.

主要方法:

  • 使用模拟循环循环模拟心力衰竭血液动力学.
  • 将一个HeartMate II左心室辅助装置 (LVAD) 集成到实验设置中.
  • 采用透明的大动脉根模型与生物假体来测量速度,并使用粒子成像速度计或类似技术可视化反旋转.

主要成果:

  • 在基线和减少流量条件下,大动脉鼻旋被清楚地视觉化为反旋转结构.
  • 旋仍然存在,即使中央喷气流随着LVAD速度的增加而缩小,只有当大动脉完全关闭时才消失.
  • 这项研究表明,这些旋流保留了流体的动量,并产生剪切应力,从而破坏了流动静止.

结论:

  • 在模拟的LVAD支持期间,大动脉鼻旋的持续性强调了它们在维持足够的血液流动和防止血栓形成方面的重要性.
  • 这些发现支持目前关于LVAD患者间歇性主动脉打开的建议,以保持这些有益的流动结构.
  • 这项研究提供了LVAD支持期间大动脉根形成的首次直接可视化,为进一步的临床和实验研究提供了理由.