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Updated: Jun 15, 2025

Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders
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对Dravet综合征的GABAergic发展的表观遗传洞察力 iPSC和治疗影响

Jens Schuster1, Xi Lu1, Yonglong Dang1

  • 1Department of Immunology, Genetics and Pathology, Uppsala University and Science for Life Laboratory, Uppsala, Sweden.

eLife
|August 27, 2024
PubMed
概括

德拉维特综合征 (DS) 涉及SCN1A基因变异和破坏的GABAergic内部神经元功能. 这项研究揭示了DS患者衍生的iPSC中的表观遗传异常,显示了改变的GABAergic发展和潜在的VPA治疗救援.

关键词:
有GABA活性的神经元染色质可访问性 染色质可访问性达拉维特综合征 iPSC 的情况.这是表观遗传学.人类 人类 人类 人类 人类 人类 人类再生医学是一种再生医学.干细胞是干细胞的组成部分.

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Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors07:51

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