单减弱了在急性缺氧暴露下加权鲁克运动期间的氧气脱,但不会影响认知表现
Tyler S McClure1,2, Jeffrey Phillips2, Dawn Kernagis2,3
1School of Health and Human Performance, Dublin City University, Dublin, Ireland.
Experimental physiology
|August 27, 2024
概括
外源补充剂 (R) -3-基布 (R) -3-基布酸基单 (KME) 在缺氧和运动期间改善了氧和度. 然而,在这项研究中,认知表现没有受到影响.
科学领域:
- 运动科学与医学 运动科学与医学
- 人体生理学 人体生理学
- 营养生物化学 营养生物化学
背景情况:
- 外源补充剂,特别是 (R) -3-基布 (R) -3-基布酸单 (KME),正在研究它们在缺氧条件下增强生理反应的潜力.
- 缺氧,或减少氧气的可用性,可以损害身体和认知功能,使KME补充等干预措施成为性能优化的焦点.
- 对于运动员和军事人员来说,了解急性外源症对氧和和在模拟高度运动期间的认知表现的影响至关重要.
研究的目的:
- 为了确定急性摄入R-BD R-βHB单 (KME) 是否可以减轻在低氧暴露期间氧气可用性的下降.
- 评估KME对休息状态和低氧暴露期间与中等强度运动相结合的认知表现的影响.
- 为了研究KME诱导的外源症对血液氧和的生理影响.
主要方法:
- 一个单盲随机交叉研究,涉及16名男性参与者.
- 参与者在摄入R-BD R-βHB KME或与乳糖一起服用安慰剂后,在一个正常的海拔室 (4572m) 中接受认知评估和中等强度运动 (加权鲁克).
- 在低氧暴露前和期间测量血液氧和认知性能 (使用DANA,Stroop和射击模拟任务).
主要成果:
- 摄入KME迅速增加并持续维持R-βHB度 (>3 mM).
- 低氧暴露期间氧和度的下降与安慰剂相比,KME显著减弱2.4%-4.2% (P <0.05).
- 在KME和安慰剂试验之间没有观察到认知表现结果的显著差异,无论是在休息状态还是低氧暴露期间.
结论:
- 由KME诱导的急性外源症有效地减轻了急性缺氧条件下在休息和适度运动期间血液氧和度的下降.
- 尽管改善了氧气供应,但KME补充剂并没有转化为本研究中评估的认知功能的显著改善.
- 需要进一步的研究来探索KME在不同强度和持续时间下对认知表现的微妙影响.
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