认知储备指标与心脏病和心脏结构和功能的关系:一项大型基于社区的纵向研究
Xuerui Li1, Wenzhe Yang2,3, Yuyang Miao1
1Department of Geriatrics, Tianjin Medical University General Hospital Tianjin Geriatrics Institute Tianjin China.
高认知储备 (CR) 与更好的心脏健康有关,降低心脏病 (HD) 风险和延迟发病. 这种好处超越了痴呆症预防,扩展到心血管健康.
科学领域:
- 心脏病学 心脏病学
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 已知认知储备 (CR) 可以降低痴呆风险.
- 结核硬化与心脏病 (HD) 风险和心脏功能之间的关联尚未得到充分理解.
研究的目的:
- 研究认知储备 (CR) 与患心脏病 (HD) 的风险之间的关系.
- 探索CR与心脏结构和功能的关联.
主要方法:
- 利用了来自349,907名无HD参与者的英国生物库数据.
- 开发了一个基于教育,职业,休活动和社会联系的复合CR指标.
- 使用考克斯回归,拉普拉斯回归和线性回归进行数据分析,包括心脏MRI用于子样本.
主要成果:
- 与低CR相比,高CR与任何HD (HR0.78),冠状动脉HD (HR0.68),心律失常 (HR0.91) 和心力衰竭 (HR0.63) 的风险降低有关.
- 高CR与HD发病的1.59年延迟有关.
- 高CR与心脏功能的改善相关,包括较大的左心室末缩体积,末缩体积,中风体积和射出分数.
结论:
- 提高认知储备 (CR) 与改善心脏病 (HD) 的健康结果有关.
- CR的保护作用超出了痴呆症预防范围,包括心血管健康.
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