抵抗素水平与骨矿物质密度,骨折发生之间是否存在因果关系? 一个门德尔的随机化研究
Taichuan Xu1, Chao Li1, Yitao Liao1
1Department of Spine, Wuxi Affiliated Hospital of Nanjing University of Chinese Medicine, Wuxi, Jiangsu, China.
PloS one
|August 27, 2024
概括
基因预测较高的抵抗水平与60岁以上的欧洲成年人体内总体骨矿物质密度 (TB-BMD) 的增加有关. 这项研究发现,在其他部位的抵抗素和BMD之间没有因果关系,在年轻年龄组中没有骨折风险.
科学领域:
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
- 遗传流行病学遗传流行病学
背景情况:
- 观察性研究显示,抵抗素水平与骨矿物质密度 (BMD) 或骨折风险之间存在不一致的关联.
- 抵抗素和骨健康之间的因果关系尚不清楚.
研究的目的:
- 通过使用孟德尔随机化 (MR) 调查抵抗素对骨硬化和骨折发生的因果关系.
主要方法:
- 利用了来自综合流行病学单位 (IEU) OpenGWAS数据库的全基因组关联研究 (GWAS) 数据.
- 采用逆方差权衡 (IVW) 作为主要的MR分析方法,使用加权中位数和MR-Egger进行稳定性检查.
- 使用MR-Steiger和多变量MR (MVMR) 来控制混因子,评估异质性,水平向性和因果方向.
主要成果:
- 在60岁以上的欧洲人中,在较高的抗原水平和全身 BMD (TB-BMD) 之间发现了一个可暗示的积极因果关系 (P=0.011).
- 在不同的MR方法中,结果是稳定的,没有检测到显著的异质性或质性.
- MR-Steiger 支持因果推断,而 MVMR 表示直接效应.
结论:
- 较高的基因预测抵抗水平与60岁以上欧洲成年人的结核病-BMD增加有关.
- 在0-60岁的个体中,在其他骨部位或骨折风险上的抵抗素水平和BMD之间没有发现显著的因果关系.
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