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相关概念视频

Gene Therapy00:59

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Nursing Ethical Principles II01:27

Nursing Ethical Principles II

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Ethical principles are essential in guiding nurses to fulfill their responsibilities, focusing on the quality of nursing care and decision-making. These principles, including autonomy, beneficence, non-maleficence, justice, and fidelity, shape the ethical framework within healthcare settings.
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...
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Ethics is a philosophical study of moral actions. Ethics attempts to determine what is valuable for individuals and society. It examines the rational justification of moral judgments and analyzes what is morally just, fair, and right. Bioethics is a sub-discipline of applied ethics that analyzes the philosophical, social, and legal issues in life sciences and medicine. Ethical theories serve as a foundation for decision-making and represent the viewpoints from which people seek direction. They...
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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Author Spotlight: Addressing Regulatory Gaps in Molecular Studies by Quantifying Viral Vectors in Complex Matrices
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体基因疗法:伦理和获得

Alison Bateman-House1

  • 1Division of Medical Ethics, NYU Grossman School of Medicine, New York, NY, USA;

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PubMed
概括
此摘要是机器生成的。

体基因疗法提供疾病修饰,但面临安全和获取挑战. 基因疗法开发的早期决定会对未来患者获得治疗的机会产生重大影响.

关键词:
获得新技术的机会.股权资本 股权资本伦理学 伦理 伦理学基因编辑 基因编辑基因疗法的基因治疗.

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科学领域:

  • 生物技术是生物技术.
  • 遗传学 遗传学 是一个
  • 医学伦理 医学伦理

背景情况:

  • 体基因疗法正在成为一种治疗方法,有可能改变疾病.
  • 尽管取得了进展,但关于安全性和长期疗效的重大科学不确定性仍然存在.
  • 伦理考虑,特别是关于患者获得新型基因疗法,至关重要.

研究的目的:

  • 探索基因治疗中获取问题的多方面的性质.
  • 检查在商业化之前,在开发管道的早期如何出现访问挑战.
  • 分析上游发展决策对最终患者获取的影响.

主要方法:

  • 这项研究涉及对当前基因疗法开发实践的批判性审查.
  • 分析与医疗保健干预和资源分配相关的伦理框架.
  • 检查研究和开发中的特定选择如何影响可访问性.

主要成果:

  • 基因疗法中的获取问题存在于产品进入市场之前很久.
  • 关于治疗点,载体选择和临床试验地点的决定极大地影响了可访问性.
  • 上游选择对基因治疗的开发和商业阶段都有深远的影响.

结论:

  • 解决基因疗法获取问题需要考虑产品成本以外的因素.
  • 基因疗法开发中的伦理和实际挑战必须主动管理,以确保公平的获取.
  • 需要采用整体方法来应对基因疗法的复杂性,从最初到市场.