相关实验视频

Updated: Jul 12, 2026

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube

Published on: April 28, 2020

三甲基丁化物诱导肝的氧化损伤和亡

Jianming Su¹, Meiwen Tang¹, Qing Liu¹

¹Provincial Key Laboratory of Protein Engineering in Animal Vaccines, College of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China.

Poultry science

|August 27, 2024

概括

三甲基化物 (TMT) 通过诱导氧化应激和亡,导致的肝损伤. 这种环境毒素会增加肝酶和细胞损伤,影响动物健康.

科学领域:

毒理学毒理学毒理学
环境科学环境科学
肝病学肝病学是一种肝病学.

背景情况:

三甲基化 (TMT) 是一种环境污染物,已知对人类和动物有毒.
了解TMT诱导的肝损伤的具体机制对于评估其健康风险至关重要.

研究的目的:

为了研究三甲基化物 (TMT) 对肝暴露的毒性机制.
阐明氧化应激和亡在TMT诱导的肝毒性中的作用.

主要方法:

在体内研究:口服给不同度的TMT.
试管体内研究:用TMT对12小时的雄性肝瘤细胞进行治疗.
生物化学测定 (ALB,TP,ALT,AST,GSH,MDA) 和肝脏组织和细胞的组织学检查.

主要成果:

根据剂量,TMT暴露增加了血清ALB,TP,ALT和肝脏ALT,AST.
组织学揭示了肝细胞亡,降低了谷氨 (GSH),并在肝脏组织和LMH细胞中增加了甲 (MDA).
TMT上调了与亡相关的基因 (Caspase8,Caspase3,Caspase9) 和增加了LMH细胞的晚期亡.

结论:

暴露于TMT会在肝和LMH细胞中诱导显著的氧化应激和亡.
这些细胞事件有助于在TMT暴露后观察到的肝损伤.
这些发现突显了TMT在家禽中的肝毒性潜力,并提供了对其毒性机制的见解.

关键词:

TMTT TMTT 是一个很好的方法.灭症 (apoptosis) 是一种死亡的过程.这些都是肉肉.氧化损伤是因为氧化损伤.

更多相关视频

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure

Published on: June 5, 2020

Using Chicken Embryo as a Powerful Tool in Assessment of Developmental Cardiotoxicities

Using Chicken Embryo as a Powerful Tool in Assessment of Developmental Cardiotoxicities

Published on: March 21, 2021

相关概念视频

Bioactivation and Tissue Toxicity

Bioactivation and Tissue Toxicity

Bioactivation is a metabolic process that transforms less reactive substances into highly reactive metabolites, initiating tissue toxicity. This transformation can lead to various toxic effects, including carcinogenesis and teratogenesis. Reactive metabolites are classified into two main types: electrophiles and free radicals.Electrophiles are electron-deficient species and are produced primarily by the enzyme cytochrome P-450 during the metabolism of compounds containing carbon, nitrogen, or...