在摩洛哥的乙型肝炎病毒感染的病毒学特征:一项为期十年的研究 (2014 - 2023)
Salma Madihi1, Hicham Charoute2, Samia Boukaira3
1Molecular Biology Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco; Team of Experimental Oncology and Natural Substances, Cellular and Molecular Immuno pharmacology, Sultan Moulay Slimane University, Faculty of Sciences and Technologies, Beni Mellal, Morocco.
Diagnostic microbiology and infectious disease
|August 27, 2024
概括
这项研究分析了摩洛哥804名慢性乙型肝炎患者,发现基因型D是普遍存在的. 公共卫生战略应侧重于预防乙型肝炎病毒 (HBV) 从母亲传播给婴儿.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 摩洛哥的国家战略旨在消除病毒性肝炎.
- 了解慢性乙型肝炎 (HBV) 的病毒学特征对于有效控制至关重要.
- 摩洛哥的HBV基因型和患者特征数据需要更新.
研究的目的:
- 描述和更新摩洛哥慢性乙型肝炎患者的病毒学概况.
- 为国家消除HBV的战略提供信息.
- 确定关键的人口,血清学和分子参数.
主要方法:
- 对人口统计,血清学和分子数据的回顾性分析.
- 包括804名B型肝炎表面抗原 (HBsAg) 阳性患者.
- 分析HBV病毒载量,基因型和肝酶水平.
主要成果:
- 在HBsAg阳性患者中,HBV感染的发病率为58.24%,平均年龄为46岁.
- 基因型D的流行率很高 (91.04%),其次是基因型A和E.
- 在91.04%的患者中观察到HBeAg阴性状态,与基因型D和较低的病毒载荷密切相关.
结论:
- 基因型D是摩洛哥占主导地位的HBV菌株,特别是在HBeAg阴性患者中.
- 低的同时感染率表明有针对性的干预措施是有效的.
- 产前HBsAg查和分娩剂量疫苗接种对于预防母婴传播至关重要,尤其是在COVID-19后.
相关概念视频
Retrovirus Life Cycles
43.1K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
43.1K
Arboviral Encephalitis
70
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
70
Cytomegalovirus Disease
108
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
108
Hepatitis
99
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
99
Viral Hepatitis I: Introduction
28
Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion...
28


