评估疫苗初始非标签使用的决策过程:范围审查
Kelsey Adams1, Dieynaba Diallo2, Fazia Tadount1
1Centre de Recherche, Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, Canada.
Vaccine
|August 27, 2024
概括
国家免疫组织往往缺乏对非标签疫苗推的标准化证据. 虽然近年来情况有所改善,但这些关键决策中不一致地包含了关键结果数据.
科学领域:
- 疫苗学 疫苗学 疫苗学
- 公共卫生政策 公共卫生政策
- 基于证据的医学基于证据的医学.
背景情况:
- 由于非标准化的决策过程,国家或国际免疫技术咨询小组 (NITAGs) 在制定非标签疫苗建议方面面临挑战.
- 评估支持这些新的非标签性建议的证据基础对于公共卫生至关重要.
研究的目的:
- 对NITAGs提出的支持非标签建议的证据进行范围审查.
- 评估用于制定新型非标签疫苗推的标准化和证据质量.
主要方法:
- 使用多个数据库和网站,对同行评审和灰色文献进行了系统的搜索.
- 包括新变化的疫苗可预防疾病的建议,重点关注疗效,有效性,安全性或免疫性证据.
- 不包括快速批准,个人非标签使用,被动免疫,强剂量或省级策略的建议.
主要成果:
- 从最初的搜索中总共包含了12份文件,并补充了手动搜索中的116份文件,涵盖了1982-2018年.
- 大多数建议包括安全性和免疫性数据,随机对照试验 (RCT) 是常见的,特别是基于指示的建议.
- 证据通常涉及不同于建议中指定的种群或疫苗.
结论:
- 关键的结果证据没有被NITAGs的一致地整合到非标签建议中.
- 使用的证据可能并不总是与正在考虑的确切人群或疫苗有关.
- 最近的趋势是将更关键的结果证据包括在非标签推中,主要是RCT.
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