结直肠癌中的新型药物输送系统:进展和未来前景
Raj Kamal1, Ankit Awasthi2, Priyanka Paul3
1Department of Quality Assurance, ISF College of Pharmacy, Moga, Punjab 142001, India; School of Pharmacy, Desh Bhagat University, Mandi Gobindgarh, Punjab 147301, India.
Pathology, research and practice
|August 27, 2024
概括
新型药物输送系统 (NDDS) 通过克服传统治疗的局限性并提高药物疗效,为结直肠癌 (CRC) 管理提供了一种有前途的方法.
科学领域:
- 瘤学和制药科学 医疗科学
背景情况:
- 大肠直肠癌 (CRC) 涉及异常的细胞增殖,受炎症,遗传因素和信号通路中断的影响.
- 传统的CRC治疗方法,如手术,放射和化疗,面临诸如药物溶解性,耐药性和副作用差等挑战.
研究的目的:
- 审查CRC的致病性,信号通路和生物标志物.
- 突出传统CRC疗法的局限性和新药输送系统 (NDDS) 的优势.
- 探索NDDS在CRC管理中的应用,包括临床试验和商业化配方.
主要方法:
- 关于CRC病原和治疗方式的综合文献综述.
- 分析炎症,遗传变化和信号通路在CRC发育中的作用.
- 在CRC治疗中加强药物输送的NDDS的评估.
主要成果:
- NDDS证明了药物溶解度的提高,向癌细胞的向输送和受控释放,解决了传统治疗的缺陷.
- 与传统方法相比,NDDS显示出更有效的CRC管理的巨大潜力.
结论:
- NDDS代表了CRC治疗的优质替代方案,提供更高的疗效和减少副作用.
- 进一步的研究和NDDS的临床应用对于推进CRC患者护理至关重要.
相关概念视频
01:16Drug Delivery: Overview
279
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
279
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
01:22Drug Delivery: Miscellaneous Routes
329
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
329
01:18Drug Delivery: Enteral Route
398
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
398
01:09Methods for Studying Drug Absorption: In situ
216
In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
216
01:16Methods for Studying Drug Absorption: In vitro
213
In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
213