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动脉硬与慢性病的关联:系统性审查
Angela L Beros1, John D Sluyter1, Robert Scragg1
1School of Population Health, University of Auckland, Auckland, New Zealand.
Kidney & blood pressure research
|August 27, 2024
概括
动脉硬度可能预测慢性病 (CKD) 的发病和快速衰退. 然而,其在CKD进展中的作用以及功能是否预测动脉硬性需要进一步调查.
科学领域:
- 心血管健康 心血管健康
- 腎臟病學 (nephrology) 是一種醫學專業.
- 流行病学 流行病学
背景情况:
- 慢性病 (CKD) 往往在未被发现的情况下进展,直到损失重要的功能.
- 动脉硬是CKD的潜在危险因素,可能有双向关系.
- 了解动脉硬与CKD之间的时间联系对于早期诊断和干预至关重要.
研究的目的:
- 系统地审查研究动脉硬与CKD之间的关系的队列研究.
- 确定动脉硬是否预测功能的发展,进展或快速下降.
- 为了确定功能下降是否预测未来的动脉硬.
主要方法:
- 在2023年10月之前对MEDLINE和Embase数据库进行系统审查.
- 包括的研究调查了动脉硬度 (通过脉冲波速度估计) 作为CKD的预测因素.
- 研究特征和结果的定性总结;与PROSPERO注册的审查协议.
主要成果:
- 在17项研究中,13项发现动脉硬性预测事件CKD.
- 在控制风险因素的10项研究中,有6项显示出正相关性.
- 动脉硬性在8/17项研究中预测了CKD进展,在5/8项研究中预测了脏快速衰退;一项研究表明脏功能预测了动脉硬性.
结论:
- 动脉硬似乎是发生CKD和功能迅速下降的预测因素.
- 动脉硬与CKD进展之间的关联仍然不确定.
- 需要进一步的纵向研究来澄清功能对动脉硬性的预测作用.
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