患有左心室功能障碍和左心室血栓患者的血栓栓塞事件的患病率和预测因素
Yoonsun Won1, Kyung Eun Ha2, Se-Eun Kim3
1Division of Cardiology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea.
Cardiology
|August 27, 2024
概括
与左心室血栓 (LVT) 相关的血栓栓塞事件 (TE) 在诊断后的早期最常见. 经历TEs预测未来的事件,但慢性LVT (持续≥2年) 很少导致TEs.
科学领域:
- 心脏病学 心脏病学
- 血栓形成研究研究
- 临床医学 临床医学
背景情况:
- 血栓栓塞事件 (TE) 是左心室血栓 (LVT) 患者的重大临床关注.
- 了解LVT患者中TEs的患病率和预测因素对于风险分层和管理至关重要.
- 有限的数据存在于这种人群中TEs的长期发病率和风险因素.
研究的目的:
- 在被诊断为左心室血栓 (LVT) 的患者中调查血栓栓塞事件 (TE) 的发生率和临床预测因素.
- 定义和评估LVT慢性作为TE发生的预测因素的作用.
- 确定与LVT患者TE发展相关的关键因素.
主要方法:
- 从2010年至2021年通过心声学诊断出LVT的256名患者的回顾性分析.
- 主要结局定义为TE (中风或动脉血栓栓塞) 的发生.
- 具有TE事件和没有TE事件的患者之间的临床特征的比较,重点关注预测因素.
主要成果:
- 在4年的中位数随访期间,整体TE事件率为9%.
- 大多数TEs发生在LVT诊断后3个月内;TEs在2年后变得罕见.
- 以前的TE史是一个显著的积极预测因素 (HR:5.92),而LVT慢性 (≥2年) 是一个强烈的负面预测因素 (HR:0.04).
结论:
- 与LVT相关的TE主要发生在诊断后的早期.
- 之前的TE病史是LVT患者未来TE事件的独立预测因素.
- 慢性 LVT (≥2年) 与 TE 风险显著降低有关,这表明它具有保护作用.
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