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Updated: Jun 15, 2025

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具有跨祖先差异表达的基因被丰富为祖先特异性疾病效应,可能是由于基因与环境相互作用

Juehan Wang1, Zixuan Zhang1, Zeyun Lu1

  • 1Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

American journal of human genetics
|August 27, 2024
PubMed
概括

祖先之间的遗传差异影响基因表达和疾病风险. 了解细胞类型特定的基因表达和环境相互作用是解开祖先特异性疾病影响的关键.

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Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
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