肌球蛋白和度作为输血需要的细胞内指标在瘤学患者
Kenneth A Schenkman1, Wayne A Ciesielski2, Terry B Gernsheimer3
1Departments of Pediatrics, Bioengineering, and Anesthesiology, University of Washington, Seattle, Washington, USA.
肌红蛋白和度是细胞内氧气的度量,可以帮助确定需要输血红细胞的需要. 将其与血红蛋白水平结合起来,可以优化贫血患者的输血决策.
科学领域:
- 生物医学工程 生物医学工程
- 生理学 生理学 生理学
- 在瘤学瘤学.
背景情况:
- 目前针对贫血的红细胞输血指南主要依赖于血红蛋白或血红素水平.
- 这些传统标记器并不直接评估向组织输送的氧气.
- 肌球蛋白和度提供了细胞内氧气和组织水平氧气输送的直接衡量标准.
研究的目的:
- 评估肌球蛋白和度作为评估氧气输送充足性的潜在指标.
- 为了确定肌红蛋白和值是否可以帮助做出有关红细胞输血的决定.
- 探索肌球蛋白和在优化输血策略对贫血患者的实用性.
主要方法:
- 一项试点研究使用了一种定制的光谱仪与光纤探针进行非侵入性肌肉肌球蛋白和度测量.
- 在瘤服务中心对接受计划红细胞输血的患者进行了测量.
- 输血前,输血后立即和输血后24小时记录了肌肉肌球蛋白和,以及临床数据和组织氧气值.
主要成果:
- 肌红蛋白和,反映细胞氧水平,在一些患者输血后增加.
- 在最初呈现低和水平的患者中,观察到最显著的肌球蛋白和度增加.
- 并非所有接受输血的患者都表现出肌球蛋白和度显著增加.
结论:
- 仅仅血红蛋白或血红素值可能不足以优化红细胞利用率.
- 将肌红蛋白和度测量与血红蛋白/血红素评价相结合,可以提供一种更精确的方法来识别将受益于输血的患者.
- 这种综合方法可能会导致更有生理学依据的输血决策.
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