家庭样本自收集作为克拉米迪亚和淋病的额外测试策略:系统文献综述和元分析
Amanda C Smith1, Phoebe G Thorpe2, Emily R Learner2
1Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA rqq8@cdc.gov.
BMJ global health
|August 27, 2024
概括
家庭自收集显著增加了克拉米迪亚 (Ct) 和尼塞利亚淋病 (Ng) 检测的吸收率. 这种非常准确和可接受的策略可以促进在尚未广泛使用该策略的国家进行性传播感染查.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 诊断测试 诊断测试 诊断测试
背景情况:
- 冠状病毒 (Ct) 和尼塞利亚淋病 (Ng) 感染通常无症状,需要有效的查策略.
- 在临床环境以外的样本自收集是一种增加测试的策略,显示出高的患者可接受性和准确性,与临床医生收集的样本相比.
研究的目的:
- 系统地审查和分析比较家庭样本自收集与临床采集用于CT和NG测试的研究.
- 评估家庭自收集对测试吸收,测试结果,诊断和与护理联系的影响.
主要方法:
- 在多个数据库 (Medline,Embase,Global Health,Cochrane Library,CINAHL,Scopus,临床试验) 中进行了系统的文献搜索.
- 包括的研究直接比较了自我收集的标本 (家庭/非临床) 与临床医生收集的Ct/Ng测试标本.
- 评估的结果包括测试吸收率,与护理的联系和一致性;对RCT进行了偏差风险评估.
主要成果:
- 包括19项研究 (15项RCT,4项一致性研究),共计63275名参与者.
- 与临床环境相比,在家庭自收集时,Ct或Ng的测试吸收率是家庭自收集的2.61倍.
- 在家庭和临床样本采集之间观察到很高的一致性;与护理的联系没有显著差异.
结论:
- 在家中提供样本自收集是增加性传播感染检测的有效策略.
- 这种方法在没有广泛采用非临床样本采集方法的国家特别有价值.
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