心理痛苦与炎症性肠病表现和粘膜炎症有关
Sanja Dragasevic1,2, Biljana Stankovic3, Nikola Kotur3
1Clinic for Gastroenterohepatology, University Clinical Center Serbia, Belgrade, Serbia.
Inflammatory bowel diseases
|August 27, 2024
概括
炎症性肠病 (IBD) 患者经历了显著更高的心理痛苦,包括压力,焦虑和抑郁. 这种痛苦与特定的基因表达相关,这表明心理健康和肠道炎症之间存在联系.
科学领域:
- 胃肠病学 胃肠病学
- 心理神经免疫学 心理神经免疫学
- 分子生物学分子生物学
背景情况:
- 压力是发展和恶化炎症性肠病 (IBD) 的已知危险因素.
- IBD包括慢性疾病,如克罗恩病 (CD) 和性结肠炎 (UC).
研究的目的:
- 为了调查IBD患者与非IBD个体相比,IBD患者的心理痛苦水平.
- 探索心理痛苦与IBD患者关键炎症基因表达之间的相关性.
主要方法:
- 使用感知压力量表 (PSS),患者健康问卷 (PHQ-9) 和医院焦虑和抑郁量表 (HADS) 评估压力,焦虑和抑郁.
- 在CD (n=50),UC (n=54) 和对照组 (n=100) 之间比较心理分数.
- 与IBD患者肠道粘膜中的IL17A,IL17F和IL23A基因表达相关的心理评分.
主要成果:
- IBD患者 (CD和UC) 的PSS,PHQ-9和HADS得分明显高于对照组.
- 在感知压力 (PSS) 和IL17F mRNA表达之间发现了正相关性.
- 抑郁和焦虑评分 (HADS) 与CD患者炎症的阴道粘膜中的IL23AmRNA表达正相关.
结论:
- IBD患者表现出显著增加的心理痛苦.
- 在CD患者中IL17F和IL23A基因表达升高与更高的心理痛苦有关.
- 研究结果表明,在IBD病变发生过程中,心理痛苦和炎症途径之间存在潜在的相互作用.
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