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Updated: Jun 15, 2025

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
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通过调节IRF7,SREBP2限制骨质细胞分化和活性,并限制炎症性骨质侵蚀

Haemin Kim1,2,3, In Ah Choi1,4, Akio Umemoto1

  • 1Arthritis and Tissue Degeneration Program, David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, 11366, USA.

Bone research
|August 27, 2024
PubMed
概括

固醇调节元素结合蛋白2 (SREBP2) 抑制骨质细胞的形成和骨质损失. 它的缺失加速了骨的破坏,揭示了控制病理性骨损失的新调节电路.

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