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父亲的高脂肪饮食会影响后代的体重和DNA甲基化

Michal Haberman^1,2,3, Tzlil Menashe^2,4, Nir Cohen^1,2,3

¹Faculty of Life Sciences, Bar Ilan University, Ramat-Gan, Israel.

Scientific reports

|August 27, 2024

概括

父亲接触高脂肪饮食可以通过表观遗传变化诱导后代肥胖. 父亲的精子DNA甲基化模式预测了代际肥胖的传播.

科学领域:

表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
生殖生物学生殖生物学
代谢障碍代谢障碍代谢障碍

背景情况:

肥胖是一个全球性流行病,对公共健康有重大影响.
肥胖的代际传播可能涉及表观遗传机制.
父亲饮食对后代肥胖风险的作用需要进一步调查.

研究的目的:

研究父亲表观遗传机制,特别是CpG甲基化在肥胖的跨代传播中的作用.
为了确定父亲的高脂肪饮食 (HF) 暴露是否会导致精子和后代的表观遗传变化.
为了确定涉及这种传播的特定基因和途径.

主要方法:

雄性Wistar老鼠被食高脂肪饮食或.
从这些男性中收集了精子,用于甲基化分析.
对后代进行了肥胖特征和下丘脑表观遗传修饰的评估.
减少表示双硫酸盐测序 (RRBS) 用于识别差异甲基化区域 (DMR).

主要成果:

父亲的高脂肪饮食导致后代 (男性和女性) 肥胖.
在HF养雄性和后代下丘脑的精子中观察到Pomc促进体的显著高甲基化.
超甲基化与增加的DNMT3B表达相关.
在后代的下丘脑中,RRBS确定了77个DMRs,与神经元发育途径有关.

结论:

父亲CpG甲基化是传递肥胖特征的潜在机制.
精子中的表观遗传修饰可以影响后代的代谢健康.
这些发现强调了父亲饮食对代谢疾病遗传的重要性.

关键词:

通过DNA甲基化.饮食引起的肥胖症饮食引起的肥胖症表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.在POMC中,POMC是POMC.跨代传输是跨代的传输.

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