父母和后代之间的DNA甲基化代际关联
Yu Jiang1, Hongmei Zhang2, Su Chen3,4
1Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA. yjiang4@memphis.edu.
Scientific reports
|August 27, 2024
概括
基因表观遗传或基因甲基化 (DNAm) 模式在几代人之间传递,似乎是有限的. 18岁时母亲DNA甲基化显示出与后代DNAm的最强相关性,这表明表观遗传影响的潜在窗口.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 人类遗传学 人类遗传学
- 发展生物学 发展生物学
背景情况:
- 早期的DNA甲基化 (DNAm) 模式对于疾病的发展至关重要.
- 了解代际表观遗传对公共卫生至关重要.
- 怀特岛 (IoW) 出生队列为研究家族表观遗传联系提供了一个独特的数据集.
研究的目的:
- 为了研究父母DNA甲基化与后代DNA甲基化在母亲-新生儿和父亲-新生儿对的相关性.
- 评估代际表观遗传遗传的程度.
- 为了确定显示家族相关性的特定DNA甲基化位点 (CpG).
主要方法:
- 来自IoW出生队列的父母-后代对 (n=48) 的DNA甲基化分析.
- 在后代的带血和父母的全血中测量DNAm.
- 线性回归用于评估DNAm的代际相关性,母亲的DNAm在出生,18岁和怀孕期间被评估,怀孕期间的父亲的DNAm.
主要成果:
- 18岁时母亲DNA甲基化显示出CPG的数量最多 (1829,0.54%) 具有显著的代际相关性.
- 其中,986个CpG (54%) 是已知的甲基化定量特征位点 (methQTL).
- 当在怀孕早期 (384) 或在父子对 (559) 中评估母亲DNAm时,CPG的相关性较少,这表明表观遗传遗传有限.
结论:
- DNA甲基化的代际表观遗传似乎是有限的.
- 18岁时的母亲DNA甲基化状态可能比其他时间点或父亲的影响对后代DNAm的影响更为重要,尽管很小.
- 相对相关的CpG的比例很低,凸显了调节表观遗传的复杂机制.
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