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血清微量元素在甲状腺成像报告和数据系统 (TI-RADS) 4个结节中显示与甲状腺氧化酶自身抗体的关联

Yu Lv¹, Lei Zhang², Youren Liu³

¹Public Health Department, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, 32 West Section 2, 1st Ring Road, Chengdu, 610072, China.

Scientific reports

|August 27, 2024

概括

这项研究发现血清微量元素与一般成年人甲状腺结节之间没有显著的联系. 然而,对于具有异常TPO-Ab的TI-RADS-4甲状腺结节,建议测量Ca,Zn和Mo.

科学领域:

内分泌学在内分泌学.
环境健康环境健康
临床化学临床化学

背景情况:

甲状腺结节 (TN) 是一个日益严重的全球健康问题,与微量元素暴露的联系不清楚.
之前关于微量元素和TN风险的研究得出了不确定的结果,需要进一步调查.

研究的目的:

调查血清微量元素 (Ca,Mg,V,Fe,Co,Cu,Zn,Se,Mn,Mo) 与成年人甲状腺结节风险之间的关联.
探索微量元素和甲状腺功能标记物之间的关系,特别是在TI-RADS-4结节患者中.

主要方法:

一项涉及1282名中国成年人的横截面研究,其中377人通过超声波诊断出TN.
血清微量元素使用诱导合血质谱学量化;甲状腺功能通过化学发光微粒子免疫测试进行评估.
限制立方线和贝叶斯内核机器回归模型被用于分析关联,使用倾向得分匹配调整混因子.

主要成果:

在调整了混杂因素后,在血清微量元素度和甲状腺结节的总体风险之间没有发现统计学上显著的关联.
甲状腺功能指标 (FT3,T4) 随着总微量元素混合物水平的提高而增加.
在TI-RADS-4 TN受试者中,随着微量元素混合物的增加,TPO-Ab水平上升,Ca,Zn和Mo对TPO-Ab显示相互作用的积极影响.

结论:

血清微量元素检测对于一般甲状腺结节风险评估来说似乎无关紧要.
对于TI-RADS-4甲状腺结节和异常TPO-Ab的个体,建议测量血清Ca,Zn和Mo.
需要进一步的研究,以充分阐明微量元素和甲状腺结节发育之间的复杂关联.

关键词:

横截面研究横截面研究甲状腺功能甲状腺功能甲状腺结节甲状腺结节微量元素中的微量元素.

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