对极度早产婴儿维生素D补充实践的调查
Mar Romero-Lopez1,2, Mamta Naik3, Lindsay F Holzapfel4
1Department of Pediatrics, Division of Perinatal-Neonatal Medicine, University of Texas Health Science Center Houston, McGovern Medical School, Houston, TX, USA. maria.del.mar.romerolopez@uth.tmc.edu.
Pediatric research
|August 27, 2024
概括
大多数美国新生儿重症监护室 (NICU) 给极度早产 (EP) 婴儿每天400 IU维生素D. 需要进一步的试验来确定EP婴儿的最佳维生素D补充剂,比较当前的做法与更早,更高的剂量.
科学领域:
- 新生儿医学 新生儿医学
- 儿童营养学 儿童营养学
- 内分泌学 在内分泌学.
背景情况:
- 极度早产 (EP) 婴儿通常有维生素D缺乏 (血清25-基维生素D<20 ng/mL).
- 对EP婴儿的最佳维生素D补充策略尚未得到充分确立.
- 目前的实践不同,需要临床试验设计的基线数据.
研究的目的:
- 评估美国新生儿重症监护室 (NICU) 护理EP婴儿的当前维生素D补充实践.
- 为未来关于EP婴儿维生素D补充的临床试验提供基线数据.
主要方法:
- 在美国护理EP婴儿的NICU中进行了一项在线调查.
- 用描述性统计数据分析了维生素D摄入量和补充剂的做法.
- 根据NICU附属和护理水平,对应的反应进行了比较.
主要成果:
- 253个NICU的回复表明,97%提供肠道维生素D补充剂.
- 最常见的剂量是400 IU/天 (77%),通常在既定养后开始 (71%开始于≥120 mL/kg/天).
- 几乎所有NICU (94%) 在出院时都开设了维生素D补充剂.
结论:
- 大多数美国的NICU每天给EP婴儿注射400 IU肠道维生素D.
- 需要进行临床试验,将标准治疗方案与更早,更高的剂量进行比较.
- 需要进一步的研究来确定最佳的维生素D水平和EP婴儿的补充策略,以改善结果.
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