产前维生素D缺乏症暴露导致免疫细胞比例的长期变化
Koki Ueda1,2, Shu Shien Chin3, Noriko Sato4
1Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, 10461, USA.
Scientific reports
|August 27, 2024
概括
产前维生素D缺乏通过改变免疫细胞发育,影响后代的免疫力. 怀孕期间母亲的维生素D水平显著影响婴儿免疫细胞比例,建立长期免疫记忆.
科学领域:
- 免疫学 免疫学 免疫学
- 发展生物学 发展生物学
- 营养科学 营养科学
背景情况:
- 维生素D缺乏症在全球普遍存在,特别是在生育年龄的女性中.
- 产前暴露于维生素D缺乏症可能会提高后代在以后的生活中患免疫相关疾病的风险.
- 身体"记住"发育环境暴露的机制尚不清楚.
研究的目的:
- 研究产前维生素D缺乏对后代免疫细胞组成的长期影响.
- 探索参与免疫系统对产前维生素D状态记忆的分子通路.
- 为了将孕妇在怀孕期间的维生素D水平与带血免疫细胞概况相关联.
主要方法:
- 利用通过饮食操纵创造的维生素D缺乏的小鼠来模拟产前缺乏.
- 分析了缺陷母体的后代 (胎儿和成人) 的免疫细胞比例.
- 检查的基因表达变化下游的维生素D受体信号在造血干细胞和祖细胞.
- 在75个人类怀孕中,与带血免疫细胞概况相关的第二个三个月的母亲维生素D水平.
主要成果:
- 产前维生素D缺乏会显著改变后代小鼠的免疫细胞比例.
- 这些变化与血液造血干细胞和祖细胞中维生素D受体信号调节的基因的转录性质的变化有关.
- 怀孕第二个三个月期间母亲的维生素D水平与期末后代的特定免疫细胞比例有显著的关联.
结论:
- 产前维生素D缺乏会导致免疫系统发育的长期变化.
- 血液形成的分化特性可以作为产前维生素D暴露的长期记忆.
- 在怀孕期间保持适当的母体维生素D水平对于后代的免疫健康至关重要.
相关概念视频
Development of Immunocompetence
295
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
295
Role of Skin in Vitamin D Synthesis
5.1K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.1K
Immunodeficiency Diseases
926
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
926
Immunological Memory
565
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
565
Cells of the Adaptive Immune Response
972
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
972
Factors Affecting the Risk of Infection
11.5K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.5K


