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Updated: Jun 18, 2026

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
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在1,4-二二代谢和肝毒性中的CYP2E1:来自CYP2E1淘汰赛小鼠研究的见解

Yewei Wang1,2, Georgia Charkoftaki1, David J Orlicky3

  • 1Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT, 06510, USA.

Archives of toxicology
|August 27, 2024
PubMed
概括

1,4-二氧化 (DX) 的肝脏致癌性与CYP2E1酶活性有关. 研究表明,CYP2E1缺乏可以保护DX诱导的肝损伤和氧化应激,这表明它.

关键词:
细胞染色体p450的使用情况.肝脏致癌的发生.氧化性DNA损伤导致的DNA损伤.氧化应激是一种氧化应激.水污染物的水污染物.

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