相关实验视频

Updated: Jun 15, 2025

Techniques to Induce and Quantify Cellular Senescence
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Published on: May 1, 2017

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通过IRTKS凝聚剂形成和重塑异色染色素,抵消细胞衰老

Jia Xie1, Zhao-Ning Lu1, Shi-Hao Bai1

  • 1Key Laboratory of Systems Biomedicine (Ministry of Education) and State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China.

The EMBO journal
|August 27, 2024
PubMed
概括

胰岛素受体氨酸激酶基质 (IRTKS) 通过液-液相分离驱动 heterochromatin 的形成. 缺少IRTKS会破坏基因组的稳定性,激活衰老路径.

关键词:
细胞衰老 细胞衰老异染色素形成的形成.在这里,IRTKSKS.液-液相分离器 液相分离器这就是SUMOylation的作用.

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