在儿童急性白血病治疗期间的中枢神经系统并发症
Arzu Ekici1, Bilgen Ayan2, Elif Güler Kazancı2
1Department of Pediatrics, Division of Neurology, Bursa Yuksek Ihtisas Training and Research Hospital, Mimar Sinan Avenue, Yıldırım, Bursa, Turkey. drarzuekici@gmail.com.
Acta neurologica Belgica
|August 27, 2024
概括
中枢神经系统 (CNS) 的并发症在患有急性白血病的儿童中很常见,特别是在治疗期间. 神经成像对于诊断这些各种并发症至关重要,这些并发症可能表现出类似的症状.
科学领域:
- 儿科瘤学 儿科瘤学
- 儿科神经学 儿科神经学
- 血液学 血液学 血液学
背景情况:
- 中枢神经系统 (CNS) 的并发症是儿科白血病患者的已知风险.
- 这些并发症可能来自白血病本身或化学治疗剂.
- 了解CNS问题的范围对于有效管理至关重要.
研究的目的:
- 调查急性白血病治疗儿童中枢神经系统并发症的发生率和类型.
- 为了确定急性髓性白血病 (AML) 与急性淋巴细胞白血病 (ALL) 中中枢神经系统并发症的频率.
- 确定这些并发症的时间和常见症状.
主要方法:
- 对115名患有急性白血病 (ALL和AML) 的儿童的临床记录的回顾性审查.
- 排除标准包括先前存在的神经问题或诊断时的中枢神经系统白血病.
- 收集关于中枢神经系统并发症的发生,时间,症状和结果的数据.
主要成果:
- 中枢神经系统并发症发生在AML患者中的23.1%和ALL患者中的13.5%.
- 大多数并发症发生在化疗的诱导阶段 (66.7%).
- 是最常见的症状 (50%),其次是半和头痛. 在33.3%的患者中,有毒性白血脑病症被发现.
结论:
- 儿童白血病呈现出各种各样的中枢神经系统并发症,受疾病,治疗和其他因素的影响.
- 类似的症状可以掩盖中枢神经系统问题的不同潜在原因.
- 神经成像对于准确的中枢神经系统并发症的病因诊断在儿科白血病中至关重要.
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